Silybin CAS NO.22888-70-6

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CAS number: 22888-70-6

Active ingredients:

Silybin is the mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. Both in vitro and animal research suggest that Silybin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins.

Product Characteristics

Botanical Name: Silybum marianum 

Plant Part :  Seeds of S. marianum 

Purity: ≥98% ( mixture of two diastereomers, silybin A and silybin B)

Stability: ≥2 years at -20?C

Appearance:  Yellow crystalline powder

Solvent :  Ethanol,  DMSO, and Dimethyl  formamide

Country of Origin: China

Product Information:

Silybin is sparingly soluble in aqueous buffers. For maximum  solubility in  aqueous buffers,  silybin  should first  be dissolved in DMF and then diluted with the aqueous buffer of choice. Silybin has a solubility of approximately 0.5 mg/ml in a 1:9 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

Range of application:

Silybin  is the  major flavonolignan  from  the extracts  of  milk thistle  seed, S.  marianum.  The whole  extract, known as silymarin,  has  been found  to protect  the liver  from  both acute  and chronic  toxicity and  injury.
Silybin blocks  the production of superoxide in PMA-activated  rat Kupffer cells with an EC value of around 100 µM.
Silybin also  blocks the synthesis of leukotriene B   by these same cells with an IC50 value of about 15 µM.
Thus, part of  the protective effects of silybin could be due to  5-lipoxygenase inhibition.

Storage:  ≥2 years at -20°C

Packing:  25kg barrel/ / Can  or  Depends on requirements.

Product customization:  According to customer quality standards for customization**